Determining malignancy in CT guided fine needle aspirate biopsy of subsolid lung nodules: Is core biopsy necessary?
| Autor: | Amita Sharma, Shaunagh McDermott, Nantaka Kiranantawat, Subba R. Digumarthy, Milena Petranovic, Mari Mino-Kenudson, Ashok Muniappan, Jo-Anne O. Shepard |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty medicine.medical_treatment lcsh:R895-920 Malignancy Subsolid nodule Article Ground-glass opacity 030218 nuclear medicine & medical imaging Core biopsy 03 medical and health sciences 0302 clinical medicine Fine needle aspirate Biopsy medicine Radiology Nuclear Medicine and imaging Lung cancer Lung medicine.diagnostic_test business.industry Retrospective cohort study medicine.disease Ground glass opacity Chest tube medicine.anatomical_structure Pneumothorax 030220 oncology & carcinogenesis Radiology CT guided lung biopsy medicine.symptom business |
| Zdroj: | European Journal of Radiology Open, Vol 6, Iss, Pp 175-181 (2019) European Journal of Radiology Open |
| ISSN: | 2352-0477 |
| Popis: | Highlights • CT-guided fine needle aspirate is accurate in the diagnoses of subsolid nodules. • CT-guided fine needle aspirate of subsolid nodules is safe. • A core needle biopsy is not always necessary. Purpose To assess the success of determining malignancy in subsolid lung nodules by fine needle aspirate of CT-guided transthoracic needle biopsy. Material and method This IRB approved retrospective study analyzed CTguided transthoracic needle biopsy of 86 consecutive subsolid nodules (size 25 + 14 mm; Age 71 + 10 years: M: F, 27:59), with ground glass opacity of = 50% in 64 (74%) and size < 2 cm in 38 (44%). Fine needle aspirate was performed in all and additional core biopsy in 21 (24%). The biopsy results were correlated with resected surgical pathology in 59 (69%) and by long term clinical and imaging follow-up in 27 (31%). The statistical analysis was performed by Fischer exact test to determine the success rate in < 2cm and =2cm nodules and those with 0.05), with a specificity 100% in both groups. Core biopsy altered the diagnosis only in 1/21 (4.8%). The nondiagnostic biopsy rate was 18 and 11% for lesions with =50% and 0.05). The incidence of pneumothorax was 21%, none requiring chest tube, and mild hemoptysis in 8%. Conclusion CT-guided transthoracic needle biopsy of both small and large subsolid nodules is highly sensitive and very specific for making the diagnosis of malignancy with a low rate of complications. Additional core biopsy offered no significant advantage over fine needle aspirate biopsy alone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|