Cystinosin-deficient rats recapitulate the phenotype of nephropathic cystinosis

Autor:	Jennifer A. Hollywood, Prasanna K. Kallingappa, Pang Yuk Cheung, Renita M. Martis, Sree Sreebhavan, Robert D. ‘Atiola, Aparajita Chatterjee, Emma J. Buckels, Brya G. Matthews, Paula M. Lewis, Alan J. Davidson
Rok vydání:	2022
Předmět:	Amino Acid Transport Systems Neutral Phenotype Physiology Cysteamine Cystinosis Animals Cystine Fanconi Syndrome Rats
Zdroj:	American Journal of Physiology-Renal Physiology. 323:F156-F170
ISSN:	1522-1466 1931-857X
DOI:	10.1152/ajprenal.00277.2021
Popis:	Animal models of disease are essential to perform preclinical testing of new therapies before they can progress to clinical trials. The cystinosis field has been hampered by a lack of suitable animal models that fully recapitulate the disease. Here, we generated a rat model of cystinosis that closely models the human condition in a timeframe that makes them an excellent model for preclinical drug testing as well as being a powerful tool to advance research.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b70a79432587f5b7ef3f62019aecf1e https://doi.org/10.1152/ajprenal.00277.2021 Zobrazit plný text záznamu