Severe amnestic syndrome due to theophylline toxicity
| Autor: | Eimear Joyce, Shane Davy, Diana Angelika Olszewska, Timothy J. Counihan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Case Report
Neuroimaging Hashimoto Disease Status epilepticus law.invention 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Theophylline law medicine Humans Autoimmune encephalitis business.industry Montreal Cognitive Assessment 030208 emergency & critical care medicine General Medicine medicine.disease Magnetic Resonance Imaging Intensive care unit Hyperintensity Anesthesia Encephalitis Female medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| Popis: | We report a case of severe amnestic syndrome following theophylline overdose. A woman in her early 30s was admitted to hospital where she developed status epilepticus following an intentional overdose of theophylline and lansoprazole. She developed a profound acidosis and required intubation in the intensive care unit. Following extubation the patient was noted to have a severe amnestic syndrome with poor short-term memory. A work-up to exclude infectious, autoimmune and paraneoplastic causes for encephalitis was undertaken. Cerebrospinal fluid analysis was normal and autoimmune encephalitis titres were negative. Initial MRI brain imaging demonstrated hyperintensities of the mesial temporal lobes bilaterally. Follow-up imaging at 4 months identified further interval reduction but persistent hippocampal hyperintensities. Theophylline toxicity with corresponding amnestic syndrome and hippocampal hyperintensities has been rarely reported. We believe this case with persistent abnormal Montreal Cognitive Assessment Score at 12 months correlates with persistent hippocampal abnormalities seen on imaging. |
| Databáze: | OpenAIRE |
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