Treatment of Oral Verrucous Carcinoma With Carbon Dioxide Laser
| Autor: | Suzana Cantanhede Orsini Machado de Sousa, Dante Antônio Migliari, Carlos de Paula Eduardo, Luciane Hiramatsu Azevedo, Vivian C. Galletta |
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| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty Connective tissue Antineoplastic Agents Tretinoin Carcinoma Humans Medicine Carcinoma Verrucous Oral mucosa Esophagus Aged Leukoplakia Basement membrane Wound Healing business.industry Verrucous carcinoma Neoplasms Second Primary medicine.disease Epithelium Tongue Neoplasms medicine.anatomical_structure Otorhinolaryngology Lasers Gas Female Surgery Laser Therapy Leukoplakia Oral Oral Surgery business Follow-Up Studies |
| Zdroj: | Journal of Oral and Maxillofacial Surgery. 65:2361-2366 |
| ISSN: | 0278-2391 |
| DOI: | 10.1016/j.joms.2006.10.024 |
| Popis: | Verrucous carcinoma (VC) is a slow-growing, nonmetastasizing form of squamous cell carcinoma that most frequently affects the oral mucosa, although other sites such as the larynx, esophagus, nasal fossae, skin, and genitals may also be involved. VC has an exophytic, cauliflower-like appearance and occurs predominantly in the elderly. According to most reports, the neoplasm seems to be more prevalent in men than in women. The cause is unknown, but consumption of tobacco in the form of chewing, snuffing, or heavy smoking is considered the most important factor associated with the development of VC. Other studies have investigated whether human papillomavirus (HPV), mainly genotypes 2, 6, 11, 16, and 18, could be another possible causative factor. However, most studies have failed to find a statistically significant association of any HPV genotypes with VC. Histologically, this neoplasm is characterized by a proliferation of hyperkeratotic, thickened epithelium with a papillary or verrucous surface. No invasion is observed at the connective tissue interface, only invagination of the squamous epithelial ridges. Combined characteristics such as integrity of the basement membrane and normal epithelial maturation, along with the absence of dysplastic changes, suggest that this disease is characterized by nonaggressive behavior. |
| Databáze: | OpenAIRE |
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