Prevalence of low phospholipid-associated cholelithiasis in young female patients
| Autor: | Yann Ngo, Olivier Rosmorduc, Alain Charlier, Joëlle Bonnet, David Zanditenas, Anware Maftouh, Martine Blazquez, Laurent Dugué, Véronique Barbu, Béatrice Parfait, Chant Balian, Ahmed El Naggar, Bertrand Condat, Véronique Collot, Marie-Pierre Hauuy |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty ATP Binding Cassette Transporter Subfamily B Adolescent medicine.medical_treatment DNA Mutational Analysis Gene mutation Gastroenterology Diagnosis Differential Young Adult Cholelithiasis Internal medicine Prevalence medicine Humans Point Mutation Prospective Studies ABCB11 Young female Low phospholipid-associated cholelithiasis ATP Binding Cassette Transporter Subfamily B Member 11 Phospholipids Hepatology business.industry Progressive familial intrahepatic cholestasis DNA ABCB4 medicine.disease Acute pancreatitis ATP-Binding Cassette Transporters Female Cholecystectomy France business Follow-Up Studies |
| Zdroj: | Digestive and Liver Disease. 45:915-919 |
| ISSN: | 1590-8658 |
| DOI: | 10.1016/j.dld.2013.04.002 |
| Popis: | We evaluated the prevalence of low phospholipid-associated cholelithiasis, a specific form of cholelithiasis associated with at least 2 of the 3 following criteria: first symptoms before the age of 40; intrahepatic comet tail artefacts, sludge or microlithiasis on ultrasound imaging; and recurrence of symptoms after cholecystectomy.We prospectively studied the cases of 60 consecutive female patients under 30 with symptomatic cholelithiasis.A diagnosis of low phospholipid-associated cholelithiasis was made in 14/60 patients (23%). The molecular analysis showed ABCB4 (n=4) and ABCB11 (n=4) gene mutations. Low phospholipid-associated cholelithiasis was frequently observed in non-overweight patients [13/27 (48%)], was present in most patients whose biliary symptoms occurred before the age of 18 [7/10 (70%)] and was often associated with cholangitis or acute pancreatitis [9/14 (64%), p0.05] while "common" cholelithiasis was mainly associated with cholecystitis [16/46 (35%), p0.05].Nearly one quarter of the female patients under the age of 30 admitted for symptomatic cholelithiasis had low phospholipid-associated cholelithiasis; particularly if body weight was normal, the symptoms began before the age of 18 or in the presence of severe biliary complications. |
| Databáze: | OpenAIRE |
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