Effects of vitamin A supplementation on intestinal barrier function, growth, total parasitic, and specific Giardia spp infections in Brazilian children: a prospective randomized, double-blind, placebo-controlled trial
| Autor: | Michelle P. Kvalsund, Alberto M. Soares, Bruna L L Maciel, Leah J. Barrett, Relana P. Fitzgerald, Aldo A. M. Lima, Rosa Maria Salani Mota, Richard L. Guerrant, Noélia L. Lima, William S. Blaner |
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| Rok vydání: | 2009 |
| Předmět: |
Vitamin
Giardiasis Male medicine.medical_specialty Diet therapy Placebo-controlled study Growth Gastroenterology Article law.invention chemistry.chemical_compound Feces Randomized controlled trial Intestinal mucosa Adjuvants Immunologic Double-Blind Method law Internal medicine parasitic diseases medicine Humans Intestinal Mucosa Child Vitamin A Inflammation Protozoan Infections business.industry Retinol Vitamins Diarrhea Lactoferrin chemistry Child Preschool Pediatrics Perinatology and Child Health Immunology Dietary Supplements Female GIARDIA SPP medicine.symptom business Biomarkers |
| Zdroj: | Journal of pediatric gastroenterology and nutrition. 50(3) |
| ISSN: | 1536-4801 |
| Popis: | This study evaluates the effects of retinol on intestinal barrier function, growth, total parasites, and Giardia spp infections in children in northeastern Brazil.The study was a double-blind, randomized placebo-controlled trial (http://clinicaltrials.gov; register no. #NCT00133406) involving 79 children who received vitamin A 100,000-200,000 IU (n = 39) or placebo (n = 40) at enrollment, 4, and 8 months and were followed for 36 months. Intestinal barrier function was evaluated using the lactulose:mannitol ratio test. Stool lactoferrin was used as a marker for intestinal inflammation.The groups were similar with regard to age, sex, nutritional parameters (z scores), serum retinol concentrations, proportion of lactoferrin-positive stool samples, and intestinal barrier function. The lactulose:mannitol ratio did not change during the same time of follow-up (P0.05). The proportion of lactoferrin-positive samples evaluated at 1 month did not change between groups (P0.05). Total intestinal parasitic, specifically new, infections were significantly lower in the vitamin A treatment compared with control group; these were accounted for entirely by significantly fewer new Giardia infections in the vitamin A treatment group. The cumulative z scores for weight-for-length or height, length or height-for-age z scores, and weight-for-age did not change significantly with vitamin A intervention for 36 months of follow-up.These data showed that total parasitic infection and Giardia spp infections were significantly lower in the vitamin A treatment group when compared with the placebo group, suggesting that vitamin A improves the host's defenses against Giardia infections. |
| Databáze: | OpenAIRE |
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