Laboratory and Clinical Evaluation of White Blood Cell Differential Counts: Comparison of the Coulter VCS, Technicon H-1, and 800 Cell Manual Method
| Autor: | William R. Swaim |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Systematic error medicine.medical_specialty Cell Survival business.industry Urology General Medicine AutoAnalyzer Sensitivity and Specificity Predictive value Leukocyte Count Deming regression medicine.anatomical_structure Evaluation Studies as Topic White blood cell Immunology Random error Leukocytes medicine Humans False Positive Reactions business Clinical evaluation Immature neutrophils |
| Zdroj: | American Journal of Clinical Pathology. 95:381-388 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/95.3.381 |
| Popis: | Eight hundred-cell manual white blood cell differential count evaluations of Coulter VCSTM and Technicon H-lTM included estimates of accuracy, imprecision, random and systematic errors, clinical relevance, and detection of immature neutrophils. Accuracy was acceptable, except for H-l testing of monocytes. Instrument imprecision was similar, except for tighter monocyte values as measured by the VCS. Deming regression determined random errors were greater for H-l monocytes and proportional errors were similar. Constant errors for the VCS were less than the H-l for neutrophils and monocytes and greater than the H-1 for eosinophils and lymphocytes. H-l morphologic false-negative rates were twice those for VCS. True-positive and falsenegative rates in cases with immature neutrophils were 70.6% and 20.3% for the VCS and 35% and 55.9% for the H-l. The reference false-positive rate was 4.4%. Clinically appropriate VCS flags were generated in distributionally abnormal cases. Predictive values were higher for the VCS. |
| Databáze: | OpenAIRE |
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