Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients
| Autor: | Fabio Ciceri, Giancarlo Comi, Angelo A. Manfredi, Alessandra Mandelli, Nicola Ivan Lorè, Roberto Furlan, Francesco Benedetti, Rebecca De Lorenzo, Annamaria Finardi, Cristina Tresoldi, Daniela Maria Cirillo, Massimo Filippi, Patrizia Rovere-Querini |
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| Přispěvatelé: | De Lorenzo, R, Loré, Ni, Finardi, A, Mandelli, A, Cirillo, Dm, Tresoldi, C, Benedetti, F, Ciceri, F, Rovere-Querini, P, Comi, G, Filippi, M, Manfredi, Aa, Furlan, R |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Neurology Coronavirus disease 2019 (COVID-19) Neurofilament light Intermediate Filaments tau Proteins Total tau Asymptomatic Gastroenterology law.invention 03 medical and health sciences 0302 clinical medicine Neurofilament Proteins law Internal medicine UCH-L1 Glial Fibrillary Acidic Protein medicine Humans 030212 general & internal medicine Neurofilament light chain Neuroradiology Original Communication Glial fibrillary acidic protein biology business.industry GFAP SARS-CoV-2 COVID-19 Intensive care unit biology.protein Neurology (clinical) medicine.symptom Tau business Ubiquitin Thiolesterase Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology |
| Popis: | Background and aims Patients infected with SARS-CoV-2 range from asymptomatic, to mild, moderate or severe disease evolution including fatal outcome. Thus, early predictors of clinical outcome are highly needed. We investigated markers of neural tissue damage as a possible early sign of multisystem involvement to assess their clinical prognostic value on survival or transfer to intensive care unit (ICU). Methods We collected blood from 104 patients infected with SARS-CoV-2 the day of admission to the emergency room and measured blood neurofilament light chair (NfL), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and total tau protein levels. Results We found that NfL, GFAP, and tau were significantly increased in patients with fatal outcome, while NfL and UCH-L1 in those needing ICU transfer. ROC and Kaplan–Meier curves indicated that total tau levels at admission accurately predict mortality. Conclusions Blood neural markers may provide additional prognostic value to conventional biomarkers used to predict COVID-19 outcome. Supplementary Information The online version contains supplementary material available at 10.1007/s00415-021-10595-6. |
| Databáze: | OpenAIRE |
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