Spirometry in Early Childhood in Cystic Fibrosis Patients
| Autor: | Elie Picard, Arie Augarten, Lea Bentur, Asher Barak, Tal Minuskin, Eitan Kerem, Amir Szeinberg, Hannah Blau, Yaacov Yahav, Ori Efrati, Daphna Vilozni |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Spirometry medicine.medical_specialty Cystic Fibrosis Vital Capacity Population Peak Expiratory Flow Rate Critical Care and Intensive Care Medicine Cystic fibrosis FEV1/FVC ratio Forced Expiratory Volume Internal medicine medicine Humans Child education education.field_of_study Lung medicine.diagnostic_test business.industry Respiratory disease Age Factors medicine.disease Surgery Cross-Sectional Studies medicine.anatomical_structure El Niño Case-Control Studies Child Preschool Cardiology Sputum Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Chest. 131:356-361 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.06-1351 |
| Popis: | Spirometry data in cystic fibrosis (CF) patients in early childhood is scarce, and the ability of spirometry to detect airways obstruction is debatable.To evaluate the ability of spirometry to detect airflow obstruction in CF patients in early childhood.CF children (age range, 2.5 to 6.9 years) in stable clinical condition were recruited from five CF centers. The children performed guided spirometry (SpiroGame; patented by Dr. Vilzone, 2003). Spirometry indices were compared to values of a healthy early childhood population, and were analyzed with relation to age, gender, and clinical parameters (genotype, pancreatic status, and presence of Pseudomonas in sputum or oropharyngeal cultures).Seventy-six of 93 children tested performed acceptable spirometry. FVC, FEV1, forced expiratory flow in 0.5 s (FEV0.5), and forced expiratory flow at 50% of vital capacity (FEF50) were significantly lower than healthy (z scores, mean +/- SD: - 0.36 +/- 0.58, - 0.36 +/- 0.72, - 1.20 +/- 0.87; and - 1.80 +/- 1.47, respectively; p0.01); z scores for FEV1 and FVC were similar over the age ranges studied. However, z scores for FEV0.5 and forced expiratory flow at 25 to 75% of vital capacity were significantly lower in older children compared to younger children (p0.001), and a higher proportion of 6-year-old than 3-year-old children had z scores that were2 SDs below the mean (65% vs 5%, p0.03). Girls demonstrated lower FEF50 than boys (z scores: - 2.42 +/- 1.91 vs - 1.56 +/- 1.23; p0.001). Clinical parameters evaluated were not found to influence spirometric indices.Spirometry elicited by CF patients in early childhood can serve as an important noninvasive tool for monitoring pulmonary status. FEV0.5 and flow-related volumes might be more sensitive than the traditional FEV1 in detecting and portraying changes in lung function during early childhood. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|