Vitamin D deficiency promotes large rupture-prone abdominal aortic aneurysms and cholecalciferol supplementation limits progression of aneurysms in a mouse model
| Autor: | Susan K. Morton, Corey S. Moran, Jonathan Golledge, Smriti M. Krishna, Joseph V. Moxon, Vianne Nsengiyumva, Michael W. Clarke, Sai Wang Seto |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Apolipoprotein B vitamin D Blood Pressure sclerostin 030204 cardiovascular system & hematology Muscle Smooth Vascular chemistry.chemical_compound 0302 clinical medicine Aorta Abdominal Osteopontin Research Articles Cholecalciferol Mice Knockout biology Angiotensin II General Medicine Abdominal aortic aneurysm Up-Regulation Disease Progression cardiovascular system medicine.medical_specialty Aortic Rupture Myocytes Smooth Muscle vitamin D deficiency 03 medical and health sciences Apolipoproteins E Internal medicine medicine Vitamin D and neurology Animals Humans Adaptor Proteins Signal Transducing Caloric Restriction business.industry Vitamin D Deficiency medicine.disease Mice Inbred C57BL Disease Models Animal 030104 developmental biology Endocrinology Gene Expression Regulation chemistry Cardiovascular System & Vascular Biology Dietary Supplements biology.protein Sclerostin business Ex vivo Aortic Aneurysm Abdominal |
| Zdroj: | Clinical Science (London, England : 1979) |
| ISSN: | 1470-8736 0143-5221 |
| Popis: | Vitamin D deficiency has been associated with human abdominal aortic aneurysm (AAA); however, its role in AAA pathogenesis is unclear. The aim of the present study was to investigate the effect of vitamin D deficiency on AAA development and examine if administering cholecalciferol (CCF) could limit growth of established AAA within the angiotensin-II (AngII) infused apolipoprotein E-deficient mouse model. Mice were rendered vitamin D deficiency through dietary restriction and during AngII infusion developed larger AAAs as assessed by ultrasound and ex vivo morphometry that ruptured more commonly (48% vs. 19%; P=0.028) than controls. Vitamin D deficiency was associated with increased aortic expression of osteopontin and matrix metalloproteinase-2 and -9 than controls. CCF administration to mice with established aortic aneurysms limited AAA growth as assessed by ultrasound (P |
| Databáze: | OpenAIRE |
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