Granulomatous hypophysitis: a case of severe headache
| Autor: | Siti Aishah Md Ali, Sharifah Faradila Wan Muhamad Hatta, Rohana Abdul Ghani, M Farhan Hamdan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Pituitary gland Pathology medicine.medical_specialty Hypophysitis Vision Disorders 030209 endocrinology & metabolism Disease Hypopituitarism Article 03 medical and health sciences 0302 clinical medicine Anterior pituitary medicine Humans Pituitary Neoplasms Glucocorticoids Pituitary stalk Granuloma business.industry Headache General Medicine medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Pituitary Gland Female Headaches medicine.symptom business 030217 neurology & neurosurgery Glucocorticoid Rare disease medicine.drug |
| Zdroj: | BMJ case reports. 2016 |
| ISSN: | 1757-790X |
| Popis: | Idiopathic granulomatous hypophysitis (GH) is an uncommon inflammatory disease of the pituitary with impairment of pituitary gland function due to infiltration by lymphocytes, plasma cells and macrophages. We report the case of a 39-year-old woman who presented with worsening of headaches for 1 month and blurring of vision over 5 days. An MRI revealed a homogeneous supra-sellar mass evoking a pituitary tumour with bulky pituitary stalk extending into the left and right cavernous sinuses. Hormonal investigations showed anterior pituitary hormone deficiencies; meanwhile histopathological examination revealed an aspect of hypophysitis. Clinical and radiological remission occurred immediately postglucocorticoid therapy with the addition of a steroid-sparing agent later in view of recurrence of symptoms on glucocorticoid dose reduction. GH has important diagnostic and therapeutic implications, as clinical and radiological features ameliorate via medical treatment. With further understanding and recognition of the disease, we hope to highlight a case of GH, in which signs and symptoms improved after initiation of corticosteroids. |
| Databáze: | OpenAIRE |
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