Two Weeks Too Long: Optimal Duration for Ureteral Prestenting and Its Physiologic Effects on the Ureter in a Yorkshire-Landrace Pig Model
| Autor: | Lay G. Ng, Ying Hao, Daniel Z.P. Yong, Allen Soon Phang Sim, Henry S.S. Ho, Yong W. Lim, Kheng Sit Lim |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Time Factors business.industry Swine Urology Urinary system 030232 urology & nephrology Urography Dilatation 03 medical and health sciences 0302 clinical medicine Ureter medicine.anatomical_structure 030220 oncology & carcinogenesis Models Animal Medicine Dilation (morphology) Animals Female Stents Landrace pig business |
| Zdroj: | Journal of endourology. 33(4) |
| ISSN: | 1557-900X |
| Popis: | Prestenting of the ureter is commonly performed to allow for passive dilation and better access to the urinary system during subsequent procedures. There is no level 1 evidence on the duration of prestenting and EAU guidelines suggest a 1-2 weeks duration.Our primary aim is to investigate the optimal duration required for prestenting in a porcine model. Our secondary aim is to compare the ureteral wall compliance between the stented and the unstented ureters.Three female pigs between 40 and 50 kg were used. We modified a human protocol for performing intravenous pyelograms in our study to obtain ureteral measurements on days 0, 5, 7, and 14. Unilateral stenting on days 0, 5, and 7 was performed. On day 14, bilateral nephroureterectomy was performed, and ureteral compliance was measured in the stent and unstented ureter.There were significant ureteral dilation between days 0 and 5 for all three pigs (pOur results suggest that optimal prestenting may be achieved in 5 days in a porcine model. It can potentially form the basis to start randomized human trials. |
| Databáze: | OpenAIRE |
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