Association of Fatty Acid Ethyl Esters in Meconium of Neonates with Growth Deficits at Birth: a Prospective, Single-Centre Cohort Study
| Autor: | Ho-Seok Kwak, Yeon Hee Kim, Hyun Seung Lee, J. Y. Han, Hae Kook Lee, Sun-Jin Jo |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Meconium Percentile medicine.medical_specialty Birth Outcomes Fetal alcohol syndrome Intrauterine growth restriction Pediatrics Cohort Studies 03 medical and health sciences 0302 clinical medicine Tandem Mass Spectrometry 030225 pediatrics medicine Odds Ratio Humans Prospective Studies Prospective cohort study Chromatography High Pressure Liquid Growth Deficits Meconium business.industry Obstetrics Body Weight Fatty Acids Infant Newborn Esters General Medicine Odds ratio medicine.disease Confidence interval Logistic Models ROC Curve Fetal Alcohol Spectrum Disorders Area Under Curve Original Article Female Fatty Acid Ethyl Esters Fetal Alcohol Syndrome business Head 030217 neurology & neurosurgery Biomarkers Cohort study |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | Background In this prospective cohort study, we investigated the association between fatty acid ethyl esters (FAEEs) in meconium as biomarkers of prenatal ethanol exposure and growth deficits, as birth outcomes, that constitute several of the key cardinal features of fetal alcohol syndrome. Methods A total of 157 meconium samples were collected from enrolled infants within 24 hours of birth, and nine FAEEs were quantified using liquid chromatography/tandem mass spectrometry. The relationships between cumulative concentrations of nine species of FAEEs in meconium and birth parameters of growth (age-sex-specific centiles of head circumference [HC], weight, and length) and respective and combined birth outcomes of growth deficits (HC ≤ 10th centile, weight ≤ 10th centile, and length ≤ 10th centile) were determined. Results Multivariate logistic regression analysis demonstrated that higher cumulative concentrations of meconium FAEEs correlated with elevated risks for HC and length, both, 10th percentile or less (adjusted odds ratio [aOR], 2.94; 95% confidence interval [CI], 1.12–7.74; P = 0.029) and HC and weight and length, all of them, 10th percentile or less (aOR, 3.27; 95% CI, 1.12–9.59; P = 0.031). Conclusion The elevated cumulative FAEEs in meconium were associated with combined growth deficits at birth, specifically HC and length, both, 10th percentile or less, which might be correlated with detrimental alcohol effects on fetal brain and bone development, suggesting a plausible alcohol-specific pattern of intrauterine growth restriction. Graphical Abstract |
| Databáze: | OpenAIRE |
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