Carotid body removal for treatment of chronic systolic heart failure
| Autor: | Stanislaw Tubek, Zoar J. Engelman, Artur Ruciński, Waldemar Banasiak, Emma C. Hart, Paul A. Sobotka, Marat Fudim, Przemyslaw Jazwiec, Dariusz Janczak, Piotr Niewinski, Piotr Ponikowski, Julian F. R. Paton, Ewa A. Jankowska |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Denervation
Male medicine.medical_specialty Carotid Body business.industry Peripheral chemoreceptors Exercise intolerance Middle Aged medicine.disease Peripheral medicine.anatomical_structure Anesthesia Internal medicine Heart failure Chronic Disease medicine Cardiology Heart rate variability Humans Carotid body medicine.symptom Cardiology and Cardiovascular Medicine Adverse effect business Heart Failure Systolic |
| Zdroj: | International journal of cardiology. 168(3) |
| ISSN: | 1874-1754 |
| Popis: | Background Augmented reflex response from peripheral chemoreceptors characterises chronic heart failure (CHF), contributes to autonomic imbalance and exercise intolerance and predicts poor outcome. Methods and results We present a case of a 56-year-old male patient with ischaemic CHF, who underwent surgical, unilateral carotid body resection to reduce peripheral chemosensitivity. At 2-month and 6-month follow-ups, we document a persistent decrease in peripheral chemosensitivity accompanied by an improvement in exercise capacity, sleep disordered breathing and quality of life. Autonomic balance was favourably affected as evidenced by improved heart rate variability and augmented cardiac baroreflex sensitivity. There were no procedure-related adverse events. Conclusions Denervation of a carotid body may offer a clinical strategy to restore autonomic balance and improve morbidity in heart failure (NCT01653821). |
| Databáze: | OpenAIRE |
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