Dosimetric characteristics of accelerated partial breast irradiation by interstitial multicatheter brachytherapy with intraoperative free‐hand implantation in the treatment of early breast cancer
Autor: | Hui Ling Yeh, Chuan Li, Jia‐Fu Lin |
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Rok vydání: | 2021 |
Předmět: |
interstitial brachytherapy
medicine.medical_treatment Brachytherapy Breast Neoplasms Mastectomy Segmental Imaging phantom 030218 nuclear medicine & medical imaging 03 medical and health sciences breast cancer 0302 clinical medicine Breast cancer Radiation Oncology Physics Humans Medicine Dosimetry Radiology Nuclear Medicine and imaging Radiometry Radiation treatment planning Instrumentation Early breast cancer Radiation business.industry Interstitial brachytherapy Partial Breast Irradiation Radiotherapy Dosage medicine.disease accelerated partial breast irradiation 030220 oncology & carcinogenesis Female business Nuclear medicine |
Zdroj: | Journal of Applied Clinical Medical Physics |
ISSN: | 1526-9914 |
Popis: | Introduction The aim of this study is to evaluate the characteristics of the dosimetry and the skin dose of interstitial brachytherapy by the use of the free‐hand implantation technique toward the treatment of early breast cancer. Materials & Methods Seventeen patients diagnosed with early breast cancer were selected for the study. The implantation of the catheters for postoperative interstitial brachytherapy was performed using the free‐hand technique. The total tumor dose to the tumor cavity plus 2 cm margin was 3400 cGy, twice daily for 10 fractions in 5 days. The dosage to the target and the organ at risk (OAR) were recorded for analysis. The skin dose of the patient and the phantom were measured with Gafchromic film (EBT3) and the results were compared with the skin dose calculated by the brachytherapy treatment planning system. Results The median conformal index is 94% (range 89%–99%), and the median homogeneity index is 71%. The median skin dose measured from the skin of the patients was 20.1% lower than the skin dose calculated from the treatment planning system and consistent with the phantom surface measurement experiment. There were no grade 3 or above acute toxicity recorded. Conclusions Interstitial brachytherapy by the use of the free‐hand implantation technique for early breast cancer is feasible and avoids the need for a second surgical intervention. The calculated skin dose was overestimated by at least 20%. The results of this study may help in building a modification model for the prediction of skin toxicity in any future study. |
Databáze: | OpenAIRE |
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