Psychological profiles of patients with suspected drug allergy
| Autor: | Josefina Cernadas, Eunice Dias de Castro, Ana Leblanc, Joselina Barbosa, Laura Ribeiro |
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| Rok vydání: | 2020 |
| Předmět: |
Alexithymia
medicine.medical_specialty Drug allergy Dermatology Anxiety 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Immunology and Allergy Psychological testing Psychological assessment Depression (differential diagnoses) business.industry Depression Personality type Odds ratio medicine.disease Neuroticism Confidence interval 030228 respiratory system Original Article medicine.symptom business |
| Zdroj: | Asia Pacific Allergy |
| ISSN: | 2233-8276 |
| Popis: | Background Several studies demonstrate an important association between allergic diseases and patients' psychological characteristics. Objective To evaluate any differences in the psychological characteristics of patients studied for suspected drug allergy in comparison with healthy controls. A secondary aim was to assess differences between patients with confirmed versus excluded drug allergy, with respect to the clinical aspects. Methods The psychological characteristics of 115 consecutive patients >16 years-old, studied for suspected drug allergy were assessed. They were compared with healthy controls. Four validated questionnaires were used to evaluate anxiety, depression, alexithymia, and personality type. Results Eighty-eight patients completed the evaluation: 34 had confirmed drug allergy and 33 excluded. Forty-eight healthy subjects filled the 4 questionnaires. Increased neuroticism was associated with increased odds of belonging to the excluded drug allergy group (odds ratio [OR], 1.374; 95% confidence interval [CI], 1.173-1.609). Increased neuroticism (OR, 1.244; 95% CI, 1.065-1.453) and increased anxiety (OR, 1.210; 95% CI, 1.084-1.351) were associated with increased odds of confirmed drug allergy. However, higher extraversion decreased this likelihood (OR, 0.755; 95% CI, 0.643-0.888). The odds of having confirmed drug allergy was reduced by 79.7% (OR, 0.203; 95% CI, 0.060-0.694) for patients with 2 suspected drugs and by 84.6% (OR, 0.154; 95% CI, 0.029-0.809) for those with ≥3 in comparison to those with only one. Patients with moderate to severe reactions were more likely to have confirmed drug allergy (OR, 4.295; 95% CI, 1.105-16.693) than those with milder manifestations. Conclusion Our results highlight that patients with drug allergy have a distinctive psychological profile. Psychological assessment may help to identify patients that would benefit from a targeted intervention. |
| Databáze: | OpenAIRE |
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