An Absence of Epstein-Barr Virus Reactivation and Associations with Disease Activity in People with Multiple Sclerosis Undergoing Therapeutic Hookworm Vaccination
Autor: | P. A. C. Maple, David I. Pritchard, Radu Tanasescu, Cris S. Constantinescu, Bruno Gran |
---|---|
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Immunology lcsh:Medicine medicine.disease_cause multiple sclerosis Virus Necator americanus Article Disease activity Epstein–Barr virus 03 medical and health sciences 0302 clinical medicine Immune system hemic and lymphatic diseases Drug Discovery medicine Pharmacology (medical) Pharmacology biology business.industry Multiple sclerosis lcsh:R medicine.disease Serum samples biology.organism_classification Vaccination 030104 developmental biology Infectious Diseases business disease activity 030217 neurology & neurosurgery therapeutic hookworm vaccination |
Zdroj: | Vaccines Vaccines, Vol 8, Iss 487, p 487 (2020) Volume 8 Issue 3 |
ISSN: | 2076-393X |
Popis: | Background: Epstein&ndash Barr virus (EBV) infection is strongly associated with multiple sclerosis (MS). Helminth infection can downregulate antiviral immune responses, potentially protecting against MS, but with a theoretical risk for reactivating latent EBV infection. Objective: To investigate parameters of EBV infection and their relationship with disease activity in people with MS (PwMS) therapeutically vaccinated with Necator americanus (hookworm). Methods: Sequential serum samples from 51 PwMS 26 therapeutically infected (25 larvae) with N. americanus and 25 controls were tested for EBV virus capsid antigen (VCA) IgG and IgM, EBV nuclear antigen-1 (EBNA-1) IgG, and EBV early antigen (EA) IgG. Disease activity was assessed by periodic MRI. Significance was set at p < 0.05. Results: All PwMS were EBV VCA IgG and EBNA-1 IgG positive, and 35.2% were EBV EA IgG positive. EBV antibody levels were generally stable, and EBV reactivation in PwMS was not demonstrated by significant increases in IgG titre over 12 months. Disease activity was most frequent in PwMS possessing high levels of EBV VCA IgG (> 600 units/mL) or EBNA-1 IgG (> 150 units/mL) however, there was no association with hookworm treatment. Interpretation: Therapeutic hookworm vaccination was not associated with EBV reactivation. Multiple sclerosis disease activity was associated with high levels of EBV VCA IgG or EBNA-1 IgG. |
Databáze: | OpenAIRE |
Externí odkaz: |