Effect of dietary supplementation with ultramicronized palmitoylethanolamide in maintaining remission in cats with nonflea hypersensitivity dermatitis: a double‐blind, multicentre, randomized, placebo‐controlled study

Autor: Noli, C., della Valle, M. F., Miolo, A., Medori, C., Schievano, C., Balletti, E., Beccati, M., Bomben, L., Cerqua, A., Colombo, S., Cornegliani, L., De Lucia, M., Dedola, C., Di Mattia, D., Di Tommaso, M., Fabbrini, F., Fanton, N., Ferrara, M., Ferrucci, C., Fileccia, I., Fondati, A., Furiani, N., Galeotti, F., Gandolfo, E., Graziano, L., Legnani, S., Luciani, L., Maina, E., Matricoti, I., Mazzieri, M., Monaco, M., Olivieri, L., Ortalda, C., Pandolfi, P., Pappalardo, E., Pellicoro, C., Petrini, B., Rocconi, F., Romano, E., Salvatori, R., Sartori, R., Scarampella, F., Tazzari, A., Vercelli, A., Zanna, G.
Rok vydání: 2019
Předmět:
Zdroj: Veterinary Dermatology
ISSN: 1365-3164
0959-4493
DOI: 10.1111/vde.12764
Popis: Background Feline nonflea hypersensitivity dermatitis (NFHD) is a frequent cause of over‐grooming, scratching and skin lesions. Multimodal therapy often is necessary. Hypothesis/Objectives To investigate the efficacy of ultramicronized palmitoylethanolamide (PEA‐um) in maintaining methylprednisolone‐induced remission in NFHD cats. Animals Fifty‐seven NFHD cats with nonseasonal pruritus were enrolled originally, of which 25 completed all study requirements to be eligible for analysis. Methods and materials Cats were randomly assigned to PEA‐um (15 mg/kg per os, once daily; n = 29) or placebo (n = 28) while receiving a 28 day tapering methylprednisolone course. Cats responding favourably to methylprednisolone were then administered only PEA‐um (n = 21) or placebo (n = 23) for another eight weeks, followed by a four week long treatment‐free period. Cats were maintained in the study until relapse or study end, whichever came first. Primary outcome was time to relapse. Secondary outcomes were pruritus Visual Analog Scale (pVAS), SCORing Feline Allergic Dermatitis scale (SCORFAD) and owner Global Assessment Score (GAS). Results Mean relapse time was 40.5 days (±7.8 SE) in PEA‐um treated cats (n = 13) and 22.2 days (±3.7 SE) for placebo (n = 12; P = 0.04). On Day 28, the severity of pruritus was lower in the PEA‐um treated cats compared to placebo (P = 0.03). Mean worsening of pruritus at the final study day was lower in the PEA‐um group compared to placebo (P = 0.04), whereas SCORFAD was not different between groups. Mean owner GAS at the final study day was better in the PEA‐um than the placebo‐treated group (P = 0.05). Conclusion and clinical importance Ultramicronized palmitoylethanolamide could represent an effective and safe option to delay relapse in NFHD cats.
Background – Feline nonflea hypersensitivity dermatitis (NFHD) is a frequent cause of over‐grooming, scratching and skin lesions. Multimodal therapy often is necessary. Hypothesis/Objectives – To investigate the efficacy of ultramicronized palmitoylethanolamide (PEA‐um) in maintaining methylprednisolone‐induced remission in NFHD cats. Conclusion and clinical importance – Ultramicronized palmitoylethanolamide could represent an effective and safe option to delay relapse in NFHD cats.
Databáze: OpenAIRE
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