Biological sex influences susceptibility to Acinetobacter baumannii pneumonia in mice
Autor: | Adeline Peignier, Jeremy Seto, Dane Parker, Davida S. Smyth, Silvia Pires |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Acinetobacter baumannii Male Inflammation 03 medical and health sciences Mice 0302 clinical medicine Immune system Macrophages Alveolar medicine Pneumonia Bacterial Animals Pathogen Sex Characteristics Innate immune system biology business.industry General Medicine biology.organism_classification Pre-clinical development Disease Models Animal 030104 developmental biology Infectious disease (medical specialty) 030220 oncology & carcinogenesis Immunology Alveolar macrophage Female Disease Susceptibility medicine.symptom business Acinetobacter Infections Research Article |
Zdroj: | JCI Insight |
ISSN: | 2379-3708 |
Popis: | Acinetobacter baumannii (A. baumannii) is an extremely versatile multidrug-resistant pathogen with a very high mortality rate; therefore, it has become crucial to understand the host response during its infection. Given the importance of mice for modeling infection and their role in preclinical drug development, equal emphasis should be placed on the use of both sexes. Through our studies using a murine model of acute pneumonia with A. baumannii, we observed that female mice were more susceptible to infection. Likewise, treatment of male mice with estradiol increased their susceptibility to infection. Analysis of the airway compartment revealed enhanced inflammation and reduced neutrophil and alveolar macrophage numbers compared with male mice. Depletion of either neutrophils or alveolar macrophages was important for bacterial clearance; however, depletion of alveolar macrophages further exacerbated female susceptibility because of severe alterations in metabolic homeostasis. Our data highlight the importance of using both sexes when assessing host immune pathways. |
Databáze: | OpenAIRE |
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