Effects of Black Hoof Medicinal Mushroom, Phellinus linteus (Agaricomycetes), Polysaccharide Extract in Streptozotocin-Induced Diabetic Rats

Autor: Leo J.L.D. Van Griensven, Hakan Senturk, Mustafa Yamaç, Kazim Kartkaya, Güngör Kanbak, Aysegul Oglakci, Gokhan Bayramoglu, Melih Zeytinoglu
Přispěvatelé: Anadolu Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Zeytinoğlu, Melih
Rok vydání: 2016
Předmět:
Male
endocrine system diseases
medicine.medical_treatment
Administration
Oral
02 engineering and technology
Pharmacology
medicine.disease_cause
01 natural sciences
Applied Microbiology and Biotechnology
Cathepsin B
Rats
Sprague-Dawley
chemistry.chemical_compound
Oral administration
Drug Discovery
Insulin Secretion
Medicinal fungi
Insulin
Polysaccharide
biology
Chemistry
021001 nanoscience & nanotechnology
Phellinus linteus
Biochemistry
Phellinus
BIOS Applied Metabolic Systems
Medicinal mushrooms
0210 nano-technology
medicine.drug
Streptozocin
Diabetes Mellitus
Experimental
Islets of Langerhans
Polysaccharides
Diabetes mellitus
medicine
Animals
Humans
Hypoglycemic Agents
Fruiting Bodies
Fungal
Plant Extracts
Basidiomycota
010401 analytical chemistry
biology.organism_classification
Streptozotocin
medicine.disease
0104 chemical sciences
Rats
Disease Models
Animal
Antidiabetic activity
Rat
Oxidative stress
Zdroj: Scopus-Elsevier
International Journal of Medicinal Mushrooms 18 (2016) 4
International Journal of Medicinal Mushrooms, 18(4), 301-311
ISSN: 1940-4344
1521-9437
Popis: WOS: 000383947000003
PubMed ID: 27481296
In this article we report the healing effects of a Phellinus linteus fruiting body hot water extract (PLE) in streptozotocin (STZ)-induced diabetic rats. PLE was given before and after STZ. The preprotective, protective, and postprotective effects of PLE on STZ-induced oxidative stress were studied using biochemical (caspase 3 activity, cytosolic-to-lysosomal ratio of cathepsin B and L, DNA fragmentation levels), ordinary histological and immuno-histochemical investigation parameters. Following oral administration of PLE after STZ application, the serum glucose concentration significantly decreased up to 41.13% compared with the control group (P < 0.05). The hypoglycemic potential of the PLE was further supported by an increase of insulin secretion in the islets of Langerhans. In addition, the number of cells in Langerhans islets increased by 45.89% when PLE was given after STZ application. On the other hand, the use of PLE before oxidative stress could not prevent the onset of diabetes. This is, to our knowledge, the first study of the effect of application time of orally administered Ph. linteus hot water extract on STZ-induced diabetes.
Databáze: OpenAIRE
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