Effect of reserpine and syrosingopine on the rate and contractility of the human heart
| Autor: | Herman C. Herrlich, W. Raab, Hans Marchet |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
Chronotropic
Cardiac function curve Inotrope Heart pharmacology medicine.medical_specialty Reserpine business.industry Heart medicine.disease Syrosingopine Endocrinology Heart failure Internal medicine Heart rate Cardiology Medicine Humans Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The American journal of cardiology. 7 |
| ISSN: | 0002-9149 |
| Popis: | 1. 1. The effects of rauwolfia drugs on cardiac function are complex. Prolonged administration of small doses of reserpine and syrosingopine lowered the blood pressure and reduced the heart rate and, in three subjects, exerted a negative inotropic effect on the normal heart (prolongation of the isometric contraction period of the left ventricle). This effect is presumably due to depletion of myocardial norepinephrine. An opposite reaction of the isometric period which occurred in two subjects may be attributable to the co-existing catecholamine hypersensitivity of catecholamine-depleted cardiovascular tissues. 2. 2. Exercise-induced tachycardia was generally diminished and post-exercise cardiac deceleration accentuated by administration of reserpine. 3. 3. The degree of the negative chronotropic and, to some extent, also of the negative inotropic effect of the rauwolfia drugs seems to be directly proportionate to the pre-existing basic sympathetic tone. 4. 4. Large, acutely injected “loading doses” of reserpine lowered the blood pressure within a few hours but produced inconsistent and erratic chronotropic and inotropic reactions of the heart (probably dependent on the prevalence of either liberation or early depletion of cardiac catecholamines, respectively). 5. 5. The antiadrenergic negative chronotropic and inotropic properties of the rauwolfia drugs seem to qualify them as useful agents for selected subjects displaying a potentially detrimental cardiac adrenergic preponderance, and for supplementary medication in such catecholamine-induced conditions as angina pectoris, certain types of congestive heart failure and tachycardias. |
| Databáze: | OpenAIRE |
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