Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow
Autor: | Ingrid L. Kwee, Yuji Suzuki, Tsutomu Nakada, Hironaka Igarashi |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Hydrostatic pressure Review lcsh:Chemistry glia limitans externa starling resister 0302 clinical medicine Fluid dynamics lcsh:QH301-705.5 Spectroscopy Chemistry Brain General Medicine Anatomy Computer Science Applications Aquaporin 4 medicine.anatomical_structure Blood-Brain Barrier cardiovascular system Glymphatic system Neurovascular coupling Endothelium 1.1 Normal biological development and functioning Hagen-Poiseuille equation interstitial flow Catalysis Inorganic Chemistry Lymphatic System 03 medical and health sciences Interstitial fluid Underpinning research medicine Genetics rCBF Animals Humans Physical and Theoretical Chemistry Molecular Biology Chemical Physics Organic Chemistry Neurosciences Water Extracellular Fluid Brain Disorders Physiological model 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Biophysics Hydrodynamics Neurovascular Coupling Other Biological Sciences Other Chemical Sciences 030217 neurology & neurosurgery |
Zdroj: | International Journal of Molecular Sciences, vol 18, iss 8 International journal of molecular sciences, vol 18, iss 8 International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 18, Iss 8, p 1798 (2017) |
Popis: | The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately recognized. Recent studies indicate that the mechanisms underlying brain water dynamics are distinct from systemic tissue water dynamics. Hydrostatic pressure created by the systolic force of the heart, essential for interstitial circulation and lymphatic flow in systemic circulation, is effectively impeded from propagating into the interstitial fluid inside the BBB by the tightly sealed endothelium of brain capillaries. Instead, fluid dynamics inside the BBB is realized by aquaporin-4 (AQP-4), the water channel that connects astrocyte cytoplasm and extracellular (interstitial) fluid. Brain interstitial fluid dynamics, and therefore AQP-4, are now recognized as essential for two unique functions, namely, neurovascular coupling and glymphatic flow, the brain equivalent of systemic lymphatics. |
Databáze: | OpenAIRE |
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