Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow

Autor: Ingrid L. Kwee, Yuji Suzuki, Tsutomu Nakada, Hironaka Igarashi
Rok vydání: 2017
Předmět:
0301 basic medicine
Hydrostatic pressure
Review
lcsh:Chemistry
glia limitans externa
starling resister
0302 clinical medicine
Fluid dynamics
lcsh:QH301-705.5
Spectroscopy
Chemistry
Brain
General Medicine
Anatomy
Computer Science Applications
Aquaporin 4
medicine.anatomical_structure
Blood-Brain Barrier
cardiovascular system
Glymphatic system
Neurovascular coupling
Endothelium
1.1 Normal biological development and functioning
Hagen-Poiseuille equation
interstitial flow
Catalysis
Inorganic Chemistry
Lymphatic System
03 medical and health sciences
Interstitial fluid
Underpinning research
medicine
Genetics
rCBF
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
Chemical Physics
Organic Chemistry
Neurosciences
Water
Extracellular Fluid
Brain Disorders
Physiological model
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Biophysics
Hydrodynamics
Neurovascular Coupling
Other Biological Sciences
Other Chemical Sciences
030217 neurology & neurosurgery
Zdroj: International Journal of Molecular Sciences, vol 18, iss 8
International journal of molecular sciences, vol 18, iss 8
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 8, p 1798 (2017)
Popis: The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately recognized. Recent studies indicate that the mechanisms underlying brain water dynamics are distinct from systemic tissue water dynamics. Hydrostatic pressure created by the systolic force of the heart, essential for interstitial circulation and lymphatic flow in systemic circulation, is effectively impeded from propagating into the interstitial fluid inside the BBB by the tightly sealed endothelium of brain capillaries. Instead, fluid dynamics inside the BBB is realized by aquaporin-4 (AQP-4), the water channel that connects astrocyte cytoplasm and extracellular (interstitial) fluid. Brain interstitial fluid dynamics, and therefore AQP-4, are now recognized as essential for two unique functions, namely, neurovascular coupling and glymphatic flow, the brain equivalent of systemic lymphatics.
Databáze: OpenAIRE
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