Enfermedad Celíaca del adulto: Experiencia clínica
| Autor: | Carla Mancilla A, Ana María Madrid S, Rodrigo Ledezma R, Iván Castillo M, Mauricio Rivas Q, Jorge Valenzuela E, Javier Brahm B, Gladys Smok S, Antonio Morales B, Carmen Hurtado H |
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| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Abdominal pain medicine.diagnostic_test business.industry Anemia Histology Retrospective cohort study General Medicine medicine.disease Transglutaminase Gastroenterology Gluten Surgery Diarrhea Atrophy chemistry Internal medicine Biopsy medicine Celiac disease medicine.symptom business |
| Zdroj: | Revista médica de Chile v.133 n.11 2005 SciELO Chile CONICYT Chile instacron:CONICYT |
| ISSN: | 0034-9887 |
| Popis: | The prevalence of celiac disease (CD) is unknown in Chile. We have recently noted a rise in the number of cases diagnosed among adults. Aim: To describe the clinical characteristics of a group of adult celiac patients. Patients and methods: Clinical data of patients older than 15 years with positive antitransglutaminase or antiendomysial autoantibodies and a duodenal biopsy characteristic of CD were retrospectively reviewed. Age at diagnosis, symptoms and signs and laboratory, endoscopic and histological findings, were analyzed. Results: Thirty seven patients (28 women), were studied. Median age at diagnosis was 41 years (range 15-69). Main symptoms and signs were diarrhea (78%), weight loss (38%) and abdominal pain (38%). Anemia was found in 49%, elevation of ESR in 57%, elevation of alkaline phosphatases in 54%, elevation of aspartate aminotransferase in 38% and a rise in alanine aminotransferase in 27%. Antiendomysial antibodies were positive in 17/22 (77%) and antitransglutaminase in 19/22 (86%) patients. Endoscopic findings were suggestive of CD in 47% of cases and duodenal biopsy showed intestinal villi atrophy in 34 (92%) patients. The three patients with normal histology had positive serology and a good response to gluten free diet. Conclusions: CD should be considered in the differential diagnosis of patients with unespecific digestive symptons, even when they present late in adult life. Serologic markers are a good diagnostic tool. A normal duodenal pathology does not exclude the diagnosis, if other diagnostic features are present |
| Databáze: | OpenAIRE |
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