Do Resveratrol and Dehydroepiandrosterone Increase Diminished Ovarian Reserve?
| Autor: | Bilgin Kaygisiz, Semra Yigitaslan, Fikriye Yasemin Özatik, Orhan Özatik, Kevser Erol |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty Dehydroepiandrosterone Resveratrol 03 medical and health sciences chemistry.chemical_compound Follicle-stimulating hormone Follicle 0302 clinical medicine Internal medicine medicine lcsh:R5-920 030219 obstetrics & reproductive medicine TUNEL assay business.industry Unilateral Oophorectomy General Medicine 030104 developmental biology Endocrinology chemistry Apoptosis Original Article lcsh:Medicine (General) business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Eurasian Journal of Medicine, Vol 52, Iss 1, Pp 6-11 (2020) |
| ISSN: | 1308-8742 1308-8734 |
| DOI: | 10.5152/eurasianjmed.2019.19044 |
| Popis: | OBJECTIVE: In this study, the aim is to observe changes induced by dehydroepiandrosterone (DHEA) and resveratrol (RES) in diminished ovarian follicles that was induced by 4-vinylcyclohexenediepoxide (VCD). MATERIALS AND METHODS: Twenty four Wistar albino female rats were divided into 3 groups: control, DHEA and RES. Unilateral oophorectomy was performed in control group to remove the right ovary of 4 rats and the left ovary of 4 rats. After administration of 160 mg/kg VCD, remaining ovaries were removed. Following the same VCD treatment, in DHEA and RES groups, 60 mg/kg DHEA and 20 mg/kg RES were given for 45 days respectively and residual ovaries were removed. Hematoxylin-eosin and TUNEL staining were performed. Follicle stimulating hormone (FSH), estradiol (E2) and anti-mullerian hormone (AMH) values were measured. RESULTS: In control group, VCD-induced apoptosis in follicles increased the TUNEL-positive cell counts (p |
| Databáze: | OpenAIRE |
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