Tratamiento anticoagulante en pacientes con insuficiencia cardiaca por disfunción sistólica y ritmo sinusal: análisis del registro REDINSCOR
| Autor: | Luis Alonso-Pulpón, Javier Segovia, Xavier Borrás, Patricia Avellana, Andreu Ferrero, Juan Cinca, Josep Brugada, Rafael Vázquez |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Revista Uruguaya de Cardiología, Volume: 28, Issue: 1, Pages: 111-111, Published: APR 2013 ResearcherID |
| ISSN: | 0300-8932 |
| DOI: | 10.1016/j.recesp.2011.11.012 |
| Popis: | A B S T R A C T Introduction and objectives: In patients with heart failure, left ventricular ejection fraction 35% and sinus rhythm without conditions such as atrial fibrillation, thrombus or history of thromboembolic events, the use of anticoagulation is controversial. Our objective was to evaluate the anticoagulation strategy in these patients, variables associated with its use, and its effects on various cardiovascular events. Methods: Of the patients included in the REDINSCOR registry with left ventricular ejection fraction 35% and sinus rhythm without other anticoagulation indications (including patients with heart failure from 19 Spanish centres), we compared those who received this treatment with the remaining patients. Results: Between 2007 and 2010, 2263 patients were included, of whom 902 had left ventricular ejection fraction 35% and sinus rhythm. Of these, 237 (26%) were receiving anticoagulation therapy. Variables associated with this treatment were a lower left ventricular ejection fraction, ischemic etiology, advanced functional class, wider QRS, larger left atrial diameter, and hospitalization. After 21(11-32) months of median follow-up, there were no significant differences in total mortality (14% versus 12.5%) or stroke (0.8% versus 0.9%). A propensity score adjusted multivariate analysis showed a reduction in a combined end-point including cardiac death, heart transplantation, coronary revascularization, and |
| Databáze: | OpenAIRE |
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