11q− chromosome is associated with abnormal iron stores in myelodysplastic syndromes
| Autor: | Cristina Mecucci, A Delannoy, Kristine Vermaelen, Andries Louwagie, Jean-Louis Michaux, G. Tricot, Herman Van den Berghe, Angeline Van Orshoven |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Genetic Markers Male Cancer Research medicine.medical_specialty Pathology Iron Chromosomal translocation Biology Sideroblastic anemia Bone Marrow Genetics medicine Humans Molecular Biology Aged Chromosomes Human Pair 11 Myelodysplastic syndromes Cytogenetics Chromosome Middle Aged medicine.disease Anemia Sideroblastic Chromosome Banding Leukemia medicine.anatomical_structure Karyotyping Immunology Sideroblastosis Female Bone marrow Chromosome Deletion |
| Zdroj: | Cancer Genetics and Cytogenetics. 27:39-44 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/0165-4608(87)90258-5 |
| Popis: | Nine cases of myelodysplastic syndrome with a deletion of the long arm of chromosome #11 (11q−) showed ringed sideroblasts, and three of which had an acquired sideroblastic anemia according to the criteria of the FAB classification. In contrast, among four cases of myelodysplastic syndromes with translocation of extra material to the long arm of chromosome #11 (11q+), only one showed bone marrow sideroblasts. These results strongly indicate that an 11q− chromosome is a marker of iron overload in myelodysplastic syndromes. Within the cases of 11q− associated with sideroblastosis, two cytogenetically different anomalies (i.e., terminal or interstitial deletions) were delineated. |
| Databáze: | OpenAIRE |
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