Sacubitril/Valsartan to Treat Heart Failure in a Patient with Relapsing Hairy Cell Leukaemia: Case Report
| Autor: | Stefano Bertuol, Sara Ariotti, Alessandro Lupi, Doranna De Pace, Giovanni Gaudio, Lorenzo Monti, Luigina Guasti, Irene Ferrari, Carlo Campana |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_treatment ARNI hairy cell leukaemia heart failure Case Report 030204 cardiovascular system & hematology chemotherapy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sacubitril/valsartan Obinutuzumab Internal medicine Medicine cardiovascular diseases Neprilysin Chemotherapy Ejection fraction business.industry Hairy cell leukaemia medicine.disease chemistry lcsh:RC666-701 030220 oncology & carcinogenesis Heart failure Cardiology Rituximab Cardiology and Cardiovascular Medicine business Sacubitril Valsartan medicine.drug |
| Zdroj: | Clinical Medicine Insights: Cardiology, Vol 15 (2021) Clinical Medicine Insights. Cardiology |
| ISSN: | 1179-5468 |
| Popis: | Experience with angiotensin-receptor neprilysin inhibitors (ARNI) in oncologic patients with heart failure (HF) is limited. We report a case of ARNI started as first-choice therapy in a patient with relapsing hairy cell leukaemia (HCL) and HF with depressed left ventricular ejection fraction (LVEF). A middle-aged male, previously treated with rituximab for HCL, was scheduled for cardiologic screening before starting a new antineoplastic therapy for cancer relapse. The patient had symptomatic HF with reduced LVEF and high NT-proBNP levels. In this patient, early ARNI treatment was well tolerated and produced a rapid and durable improvement of symptoms, LVEF and NT-proBNP levels. Consequently, the oncologic team could start an experimental treatment with obinutuzumab, with complete HCL remission. In conclusion, in this patient with HCL and HF, ARNI therapy was safe and effective, contributing to undelayed cancer treatment. |
| Databáze: | OpenAIRE |
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