Hydrogel-Based Therapy for Brain Repair After Intracerebral Hemorrhage
| Autor: | Motoichi Kurisawa, Myron Spector, Kimberly A. Leite-Morris, Emiri T. Mandeville, Magdy Selim, Ding Weng, Eng H. Lo, Teck Chuan Lim, Li-Shan Wang |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty food.ingredient Neurology Striatum Matrix (biology) Gelatin Rats Sprague-Dawley 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine food Epidermal growth factor Precursor cell medicine Animals cardiovascular diseases Cerebral Hemorrhage Intracerebral hemorrhage Epidermal Growth Factor business.industry General Neuroscience Brain Hydrogels medicine.disease nervous system diseases Disease Models Animal Neuroprotective Agents 030104 developmental biology Neurology (clinical) Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Immunostaining |
| Zdroj: | Translational Stroke Research. 11:412-417 |
| ISSN: | 1868-601X 1868-4483 |
| Popis: | We assessed an injectable gelatin hydrogel containing epidermal growth factor (Gtn-EGF) as a therapy for intracerebral hemorrhage (ICH). ICH was induced in rats via collagenase injection into the striatum. Two weeks later, Gtn-EGF was injected into the cavitary lesion. The hydrogel filled ICH cavities without deforming brain tissue. Immunostaining demonstrated that neural precursor cells could migrate into the matrix, and some of these differentiated into neurons along with the appearance of astrocytes, oligodendrocytes, and endothelial cells. Sensorimotor tests suggested that Gtn-EGF improved neurological recovery. This study provides proof-of-principle that injectable biomaterials may be a translationally relevant approach for treating ICH. |
| Databáze: | OpenAIRE |
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