Pharmacological actions of substance P in the rat vas deferens

Autor:	E.H. Fernández, Hugo F. Miranda, N. Cuevas, D. Bustamante, W.W. Wolstenholme, W.I. Silva, A. Ucros
Rok vydání:	1991
Předmět:	Male medicine.medical_specialty Neuropeptide Substance P Stimulation Biology Neurotransmission Synaptic Transmission Cellular and Molecular Neuroscience chemistry.chemical_compound Vas Deferens Endocrinology Smooth muscle Internal medicine medicine Animals Receptor Neurons Dose-Response Relationship Drug Endocrine and Autonomic Systems Vas deferens Muscle Smooth Rats Inbred Strains General Medicine Receptors Neurokinin-1 Electric Stimulation Rats Receptors Neurotransmitter medicine.anatomical_structure Neurology chemistry Synapses medicine.symptom Muscle Contraction Muscle contraction
Zdroj:	Neuropeptides. 18:209-213
ISSN:	0143-4179
DOI:	10.1016/0143-4179(91)90149-d
Popis:	SP produces two different muscular responses in the isolated vas deferens of the rat. 1) A myotropic, post-synaptic effect that results from stimulation of one subtype of SP receptor, located on the membrane of the smooth muscle (NK-3 receptor). 2) A neurogenic effect at the pre-synaptic level that results from stimulation of another subtype of SP receptor, located on the nerve terminals (NK-1 receptor).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b41ff1934a0678c8babcf97dae6d54f https://doi.org/10.1016/0143-4179(91)90149-d Zobrazit plný text záznamu