VEGF −460C>T polymorphism and cancer risk: a meta-analysis
| Autor: | Bin Xu, Hong-Fei Wu, Lin-Xin Hua, Zi-Dun Wang, Na Tong, Wei Zhang, Ninghan Feng |
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| Rok vydání: | 2009 |
| Předmět: |
Vascular Endothelial Growth Factor A
Oncology Cancer Research medicine.medical_specialty Pathology Metastasis chemistry.chemical_compound Risk Factors Neoplasms Internal medicine Ethnicity Humans Medicine Polymorphism Genetic Hematology business.industry Case-control study General Medicine Odds ratio medicine.disease Confidence interval Vascular endothelial growth factor chemistry Case-Control Studies Meta-analysis Etiology business |
| Zdroj: | Medical Oncology. 27:1031-1036 |
| ISSN: | 1559-131X 1357-0560 |
| DOI: | 10.1007/s12032-009-9329-2 |
| Popis: | Vascular endothelial growth factor (VEGF) is a major driver of physiological and pathological angiogenesis and plays important roles in the etiology and metastasis of cancers. The −460C>T polymorphism in VEGF gene region has been implicated in cancer risk and related to VEGF expression. However, published data remain conflicting. To derive a more precise estimation, a meta-analysis of 5,863 cases and 5,276 controls from 14 published case–control studies was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. VEGF −460T represented a risk factor for cancers in Asians (OR = 1.69, 95% CI: 1.09–2.62) but not in Europeans (OR = 0.92, 95% CI: 0.78–1.08). Our meta-analysis showed the evidence that VEGF −460T was associated with increased cancer risk in Asians. Further prospective researches with larger numbers of worldwide participants are expected to validate this result. |
| Databáze: | OpenAIRE |
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