A comparison of the reinforcing efficacy of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') with cocaine in rhesus monkeys
| Autor: | Jason T. Ross, Michael A. Nader, Joshua A. Lile |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.drug_class N-Methyl-3 4-methylenedioxyamphetamine media_common.quotation_subject Ecstasy Self Administration Toxicology Cocaine Dopamine Uptake Inhibitors mental disorders medicine Animals Pharmacology (medical) media_common Pharmacology Local anesthetic Addiction Amphetamines Breaking point MDMA medicine.disease Macaca mulatta Substance abuse Psychiatry and Mental health Anesthesia Hallucinogens Psychology Reinforcement Psychology psychological phenomena and processes medicine.drug |
| Zdroj: | Drug and Alcohol Dependence. 78:135-140 |
| ISSN: | 0376-8716 |
| DOI: | 10.1016/j.drugalcdep.2004.10.006 |
| Popis: | The purpose of the present study was to compare the reinforcing efficacy of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to cocaine. Rhesus monkeys (n=4) responded under a within-session, exponentially increasing, progressive-ratio (PR) schedule of cocaine reinforcement. Breaking point (BP) for the PR schedule was defined as the final response requirement completed before 2 h had elapsed without an injection delivered. Saline and doses of cocaine (0.003-0.3 mg/kg/injection) and MDMA (0.01-0.56 mg/kg/injection) were substituted for the training dose of cocaine for at least five consecutive sessions. Both cocaine and MDMA functioned as reinforcers, but self-administration of MDMA occurred at fewer doses and a significantly lower peak BP was obtained for MDMA. These data demonstrate that MDMA functions as a reinforcer, although its reinforcing efficacy appears to be less than that of cocaine. |
| Databáze: | OpenAIRE |
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