One bis-indole alkaloid-voacamine from Voacanga africana Stapf: biological activity evaluation of PTP1B in vitro utilizing enzymology method based on SPRi expriment
| Autor: | Wen-Ying Huai, Rong-Qiang Liu, Wei-Jun Ding, Jin-Shuang Zhao, Tiane Zhang, Hong-Xiang Li, Yun Deng, Yan-Qiu Wang, Xiao-Chun Liu |
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| Rok vydání: | 2018 |
| Předmět: |
biology
010405 organic chemistry Activity inhibition Chemistry Alkaloid Organic Chemistry Biological activity Plant Science biology.organism_classification 01 natural sciences Biochemistry In vitro 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Voacanga africana Surface plasmon resonance imaging heterocyclic compounds Bis indole Tyrosine hormones hormone substitutes and hormone antagonists |
| Zdroj: | Natural Product Research. 33:3459-3463 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2018.1480623 |
| Popis: | One known bis-indole alkaloid-voacamine was isolated from Voacanga africana Stapf and Surface Plasmon Resonance imaging (SPRi) exprement showed that this alkaloid could be combine with Protein Tyrosine Phosphatase1B (PTP1B). Then the PTP1B activity inhibition experiment display that the compound showed an outstanding promoting activity to PTP1B. |
| Databáze: | OpenAIRE |
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