Two calix[4]pyrroles as potential therapeutics for castration-resistant prostate cancer
| Autor: | Imene Ben Toumia, Marco Ponassi, Paola Barboro, Erika Iervasi, Gabriela Coronel Vargas, Barbara Banelli, Stefano Fiordoro, Leila Chekir Ghedira, Franz Heinrich Kohnke, Alberto Izzotti, Camillo Rosano |
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| Rok vydání: | 2022 |
| Předmět: |
Pharmacology
Male Cancer Chemoresistance Drug development New anticancer drugs Prostate cancer Tumour drug resistance calix[4]pyrroles Mice Inbred BALB C Antineoplastic Agents Porifera Mice Prostatic Neoplasms Castration-Resistant Oncology Cell Line Tumor Leukocytes Mononuclear Animals Humans Pharmacology (medical) Pyrroles |
| Zdroj: | Investigational new drugs. 40(6) |
| ISSN: | 1573-0646 |
| Popis: | Macrocyclic compounds meso-(p-acetamidophenyl)-calix[4]pyrrole and meso-(m-acetamidophenyl)-calix[4]pyrrole have previously been reported to exhibit cytotoxic properties towards lung cancer cells. Here, we report pre-clinical in vitro and in vivo studies showing that these calixpyrrole derivatives can inhibit cell growth in both PC3 and DU145 prostatic cancer cell lines. We explored the impact of these compounds on programmed cell death, as well as their ability to inhibit cellular invasion. In this study we have demonstrated the safety of these macrocyclic compounds by cytotoxicity tests on ex-vivo human peripheral blood mononuclear cells (PBMCs), and by in vivo subcutaneous administration. Preliminary in vivo tests demonstrated no hepato-, no nephro- and no genotoxicity in Balb/c mice compared to controls treated with cisplatin. These findings suggest these calixpyrroles might be novel therapeutic tools for the treatment of prostate cancer and of particular interest for the treatment of androgen-independent castration-resistant prostate cancer. |
| Databáze: | OpenAIRE |
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