Mitochondria and regulated tyrosine nitration

Autor:	T, Koeck, D J, Stuehr, K S, Aulak
Rok vydání:	2005
Předmět:	Oxidative Stress Nitrogen Animals Homeostasis Tyrosine Energy Metabolism Nitric Oxide Protein Processing Post-Translational Biochemistry Mitochondria Signal Transduction
Zdroj:	Biochemical Society Transactions. 33:1399-1403
ISSN:	1470-8752 0300-5127
DOI:	10.1042/bst0331399
Popis:	The conditions of the cellular microenvironment in complex multicellular organisms fluctuate, enforcing permanent adaptation of cells at multiple regulatory levels. Covalent post-translational modifications of proteins provide the short-term response tools for cellular adjustment and growing evidence supports the possibility that protein tyrosine nitration is part of this cellular toolkit and not just a marker for oxidative damage. We have demonstrated that protein tyrosine nitration fulfils the major criteria for signalling and suggest that the normally highly regulated process may lead to disease upon excessive or inappropriate nitration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3aa94f92c3f977df817223be6ef5bd https://doi.org/10.1042/bst0331399 Zobrazit plný text záznamu