Association of the bradykinin receptors genes variants with hypertension: a case–control study and meta-analysis
| Autor: | Zhao Li, Wei Gu, Zuoguang Wang, Jilin Liu, Ya Liu, Shaojun Wen |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Oncology China medicine.medical_specialty Genotype Receptor Bradykinin B2 Physiology Subgroup analysis 030204 cardiovascular system & hematology Biology Receptor Bradykinin B1 Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Internal medicine Internal Medicine medicine TaqMan Humans Genetic Predisposition to Disease 030212 general & internal medicine Allele Receptor Alleles Genetics Case-control study General Medicine Middle Aged Case-Control Studies Meta-analysis Hypertension Female |
| Zdroj: | Clinical and Experimental Hypertension. 38:100-106 |
| ISSN: | 1525-6006 1064-1963 |
| Popis: | The present study was to investigate the role of bradykinin receptors genes polymorphisms on hypertension risk in Northern Han Chinese population. We also carried out a meta-analysis on Chinese to derive a more full assessment of this association.A total of 976 subjects from Northern Han Chinese and 7 studies with 1599 cases and 1425 controls were included in this case-control study and in the current meta-analysis, respectively. For the case-control study, we identified the genotypes of -58T/C and 1098A/G polymorphism in BDKRB2 and BDKRB1 genes, respectively, by TaqMan PCR method. Overall, we found significant association between the -58T/C polymorphism and the increased risk of hypertension in the allele comparison (p = 0.01, OR = 1.386, 95% CI [1.138-1.688]). Subgroup analysis by gender suggested that this obvious association could still be found in males, but not in females. For the 1098A/G polymorphism, no significant association was revealed in overall and subgroup analysis. For the meta-analysis involving the -58T/C polymorphism, a significant association between this polymorphism and hypertension was observed in the whole group. In Chinese Han subgroup, we found significant association with hypertension in allele comparison(C vs. T: p = 0.03, OR = 1.28, 95% CI 1.03-1.59, pheterogeneity = 0.05).Our case-control study indicated that -58T/C might be significantly associated with the increased risk of hypertension in Northern Han Chinese population, which was partially confirmed by our meta-analysis. |
| Databáze: | OpenAIRE |
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