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Department of Chemistry, Saurashtra University, Rajkot-360 005, Gujarat, India E-mail: drhsjoshi49@gmail.com Manuscript received 27 August 2008, accepted 21 October 2008 A wide range of biological activities are associated with 1,4-dihydropyridines Individually or in combination. The synthesis of N-aryl-2,6-dimethyl-3,5-dicarbmethoxy-4-(5' -(m-chloro-p-flourophenyl)·2' -furyl]-1,4-dihydropyridines (6a-j) and N-aryl-2,6-dimethyl-3,5-dicarbmethoxy-4-[5'-(m-chloro-p-flourophenyl)-2'-furyl]-1,4-dibydropyridines (7a-J) was under-taken with hope that they may be biologically active molecules with Improved activity, less toxicity and undesirable side effects. The newly synthesized compounds were characterized on the basis of elemental analysis, IR, 1H NMR and mass spectral data. All newly synthesized compounds were tested for their antitubercular activity against Mycobacterium tuberculosis H37RV ATCC 27294, antibacterial activity against different Gram +ve and Gram -ve bacteria and antifungalactivity. |
