Design, synthesis of novel N prenylated indole-3-carbazones and evaluation of in vitro cytotoxicity and 5-LOX inhibition activities
| Autor: | G. Trimoorthulu, Y.L.N. Murthy, M.S. Bethu, C.V. Rao, Praveen Choppara, Y. V. S. S. Prasad, G.U. Maheswara Rao, K. Hari Krishna, J. Venkateswara Rao |
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| Rok vydání: | 2019 |
| Předmět: |
Indole test
Chemistry(all) biology Stereochemistry Chemistry Cytotoxicity General Chemical Engineering fungi In vitro cytotoxicity In vitro toxicology Brine shrimp General Chemistry 5-Lipoxygenase inhibition biology.organism_classification lcsh:Chemistry lcsh:QD1-999 Biochemistry Prenylation Chemical Engineering(all) N prenylated indole-3-carbazones Cytotoxic T cell Bioassay Brine shrimp lethality bioassay |
| Zdroj: | Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 2328-2335 (2019) |
| ISSN: | 1878-5352 |
| Popis: | A series of novel N-1 and C-3 substituted indole derivatives (5a–f) were designed, synthesized and evaluated for their cytotoxic properties, viz Brine Shrimp Lethality Bioassay (BSLB) besides 5-Lipoxygenase (5-LOX) inhibitory activities through in vitro assays. Structure Activity Relation (SAR) studies showed that compound 5d with an LC50 of 6.49 μM and 5c with an IC50 of 33.69 μM were found to be interesting for cytotoxicity and 5-LOX inhibitory activity respectively. Keywords: Brine shrimp lethality bioassay, Cytotoxicity, 5-Lipoxygenase inhibition, N prenylated indole-3-carbazones |
| Databáze: | OpenAIRE |
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