Long-term liver histology improvement in patients with chronic hepatitis C and sustained response to interferon
| Autor: | Toccaceli, F, Laghi, V, Capurso, L, Koch, M, Sereno, S, Scuderi, M, Stellini, R, Cristini, G, Zammataro, M, Russello, M, Pizzigallo, E, Vecchiet, J, Guaglianone, L, Vigna, L, Frugiuele, Pl, Milani, S, Pignalosa, P, De Conca, V, Mesiti, S, Castellacci, R, Mignani, El, Artioli, Sl, De Luca Andrioli, E, Maci, Am, Ascione, A, De Luca, M, Persico, M, Palmentieri, B, Esposito, P, Iuliano, D, Tarantino, G, Conca, P, Scolastico, C, Stanzione, M, Colletta, C, Montalto, G, Vuturo, O, Tripi, S, Alessandri, A, Sabatella, C, De Stefano, G, Ceglia, T, Fornaciari, G, Castagnetti, E, Barlattani, A, Veglio, V, Bonasso, M, Starnini, G, Scotto, G |
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| Přispěvatelé: | Toccaceli, Fabrizio, Laghi, V., Capurso, Mauro, Koch, M., Sereno, S., Scuderi, M., Stellini, R., Cristini, G., Zammataro, M., Russello, M., Pizzigallo, E., Vecchiet, J., Guaglianone, L., Vigna, L., Frugiuele, P. L., Milani, S., Pignalosa, P., De Conca, V., Mesiti, S., Castellacci, R., Mignani, E., Artioli, S., De Luca Andrioli, E. P., Maci, A. M., Ascione, A., De Luca, M., Persico, M., Palmentieri, B., Esposito, P., Iuliano, D., Tarantino, Giovanni, Conca, P., Scolastico, C., Stanzione, M., Colletta, C., Montalto, G., Vuturo, O., Tripi, S., Alessandri, A., Sabatella, C., De Stefano, G., Ceglia, T., Fornaciari, G., Castagnetti, E., Barlattani, A., Veglio, V., Bonasso, M., Starnini, G., Scotto, G. |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Pathology Hepacivirus Biopsy Alpha interferon Infectious Disease Chronic hepatitis C Gastroenterology Statistics Nonparametric Fibrosis Recurrence Virology Internal medicine medicine Humans Multicenter Studies as Topic Aged Retrospective Studies Hepatology medicine.diagnostic_test biology business.industry Interferon-alpha Retrospective cohort study Alanine Transaminase Hepatitis C Liver biopsy Hepatitis C Chronic Middle Aged biology.organism_classification medicine.disease Infectious Diseases Alanine transaminase HCV biology.protein Interferon RNA Viral Female business chronic hepatitis c hcv interferon liver biopsy |
| Zdroj: | Journal of viral hepatitis. 10(2) |
| ISSN: | 1352-0504 |
| Popis: | A retrospective multicentre survey was conducted to evaluate, in patients with chronic hepatitis C, the long-term liver histological changes induced by interferon (IFN). A total of 112 patients (mean age 46.4 years) were studied. All patients had received a 6-12-month IFN-alpha course (6-18 MU/week) and had successively undergone clinical, biochemical and virological follow-up for at least 36 months (range: 36-76). In each patient, two liver biopsies had been performed: 1-6 months before treatment and, 12-76 months after its completion. In 87 patients with biochemical and virological sustained response persisting for 12 months after therapy, post-treatment liver necroinflammation and fibrosis mean(+/-SD) scores (Knodell index) were significantly lower than pretreatment scores (2.9 +/- 2.2 vs 6.8 +/- 2.9 and 0.8 +/- 1.0 vs 1.2 +/- 1.1, respectively; P0.01). In 25 patients who relapsed within 1 year, necroinflammation and fibrosis post-treatment mean scores were similar to pretreatment scores (7.4 +/- 3.2 vs 6.9 +/- 3.1 and 1.8 +/- 1.3 vs 1.6 +/- 1.2, respectively; P0.05). On an individual basis, necroinflammation decreased in 87% of sustained responders but only in 36% of relapsers (P0.001), whereas fibrosis decreased in 44% of sustained responders but only in 14% of relapsers (P0.001). In sustained responders with biopsies performed 12-23 months (n=34), 24-35 months (n=26) or more than 36 months (n=27) after treatment, a progressive decrease of mean necroinflammatory score was observed (-2.6 +/- 2.1, -4.1 +/- 3.4 and -5.2 +/- 3.7 points, respectively; P0.01). A similar pattern was observed in fibrosis score (-0.3 +/- 0.6, -0.3 +/- 0.7 and -0.7 +/- 0.9 points, respectively; P0.05). Hence, among chronic hepatitis C patients treated with IFN, those with a 12-month sustained response, unlike those who relapse, have a long-term progressive reduction and, in some cases, a complete regression of liver histological damage. |
| Databáze: | OpenAIRE |
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