Perivascular cholinesterase and morphological blood-brain barrier function
| Autor: | Jan Erik Hardebo, Christer Owman |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Physostigmine Pharmacology Blood–brain barrier Capillary Permeability medicine Animals Cholinesterases Barrier function Cholinesterase biology Chemistry General Medicine Capillaries Rats medicine.anatomical_structure Neurology Blood-Brain Barrier biology.protein Cholinergic Neurology (clinical) medicine.symptom Hypercapnia Neuroscience Function (biology) medicine.drug |
| Zdroj: | Acta Neurologica Scandinavica. 70:438-442 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.1984.tb00849.x |
| Popis: | – Little is known about the function of cholinesterase activity present in the walls of cerebral microvessels. It has been shown that systemically administered physostigmine, a cholinesterase inhibitor that penetrates the blood-brain barrier, causes barrier opening. This has led to suggestions that perivascular cholinesterase is involved in the maintenance of morphological blood-brain barrier function. The present study demonstrates that the physostigmine-induced barrier opening is fully attributable to the acute hypertension and hypercapnia the agent gives rise to. Thus, it is discussed whether the enzyme activity may function as an enzymatic barrier to cholinergic agents. |
| Databáze: | OpenAIRE |
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