Characterization of ESBL disseminating plasmids
| Autor: | Alma Brolund, Linus Sandegren |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Gene Transfer Horizontal 030106 microbiology Microbial Sensitivity Tests Drug resistance beta-Lactams beta-Lactam Resistance beta-Lactamases Microbiology 03 medical and health sciences Plasmid Enterobacteriaceae Molecular genetics medicine Typing Gene Molecular Epidemiology General Immunology and Microbiology biology Enterobacteriaceae Infections Outbreak General Medicine biology.organism_classification Anti-Bacterial Agents Infectious Diseases Conjugation Genetic Bacteria Plasmids |
| Zdroj: | Infectious Diseases. 48:18-25 |
| ISSN: | 2374-4243 2374-4235 |
| DOI: | 10.3109/23744235.2015.1062536 |
| Popis: | Bacteria producing extended-spectrum β-lactamases (ESBLs) constitute a globally increasing problem that contributes to treatment complications and elevated death rates. The extremely successful dissemination by ESBL-producing Enterobacteriaceae during the latest decades is a result of the combination of mobilization, evolution and horizontal spread of β-lactamase genes on plasmids. In parallel, spread of these plasmids to particularly well-adapted bacterial clones (outbreak clones) has expanded. In this review we describe ESBL-producing bacteria and the genetic mechanisms for dissemination of ESBL resistance. We describe available methodology for studying plasmids and the importance of including plasmids in epidemiological typing as natural parts of the organisms. Plasmids play a fundamental role in how resistance arises and disseminates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|