Quantitative Trait Loci Affecting Prion Incubation Time in Mice
| Autor: | Christine Ebeling, Stanley B. Prusiner, Stephen J. DeArmond, Kami E. Chiotti, Dennis A. Stephenson, George A. Carlson, Darlene Groth |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Time Factors PrPSc Proteins Genetic Linkage Ratón animal diseases Mice Inbred Strains Chromosome 9 Scrapie Quantitative trait locus Biology Prion Diseases Incubation period Mice Quantitative Trait Heritable Species Specificity Gene mapping Genetics Animals Incubation Gene Crosses Genetic Genome Chromosome Mapping nervous system diseases Female Lod Score Microsatellite Repeats |
| Zdroj: | Genomics. 69:47-53 |
| ISSN: | 0888-7543 |
| Popis: | Although the gene encoding prion protein (PrP) is the major determinant of susceptibility to prion disease, other genes also affect prion incubation time in mice and may be involved in prion replication. Scrapie incubation time was analyzed as a quantitative trait using crosses between SJL/J and CAST/Ei mice; these mouse strains encode identical PrP molecules but have different incubation periods. Our analysis revealed loci on Chromosomes 9 and 11 that affect prion susceptibility. |
| Databáze: | OpenAIRE |
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