Novel analgesics and molecular rearrangements in the morphine-thebaine group. XXVI. Some reactions of the thebaine-2-chloroacrylonitrile adduct

Autor:	J. W. Lewis, M. J. Readhead, Alan C. B. Smith
Rok vydání:	1972
Předmět:	Analgesics Thebaine Chemical Phenomena Morphine chemistry.chemical_element Medicinal chemistry Adduct chemistry.chemical_compound Chemistry chemistry Nucleophile Acrylates Morpholine Alkoxide Nitriles Chlorine medicine Organic chemistry Hydrogenation medicine.drug Carbanion
Zdroj:	Journal of the Chemical Society. Perkin transactions 1. 6
ISSN:	0300-922X
Popis:	Catalytic hydrogenation and treatment with nucleophiles (Grignard reagent, alkoxide ions, morpholine) results in loss of chlorine from the thebaine–2-chloroacrylonitrile adduct. The products of the latter reactions are derived from the C-7 carbanion (5) and the 7,8-unsaturated 7-carbonitrile (9), in most cases by processes involving rearrangements.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b32dd4a63e40d87370d10a933b56502 https://pubmed.ncbi.nlm.nih.gov/5064154 Zobrazit plný text záznamu