Glycated low density lipoprotein catabolism is increased in rabbits with alloxan-induced diabetes mellitus
| Autor: | W. Kortlandt, C. Benschop, H. J. M. Van Rijn, D. W. Erkelens |
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| Rok vydání: | 1992 |
| Předmět: |
Glycation End Products
Advanced Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Diabetes Mellitus Experimental chemistry.chemical_compound Glycation Reference Values Alloxan Internal medicine Diabetes mellitus Internal Medicine medicine Animals Triglycerides Apolipoproteins B Glycated Hemoglobin Lagomorpha biology Catabolism business.industry Metabolism biology.organism_classification medicine.disease Lipoproteins LDL Kinetics Endocrinology Cholesterol chemistry Low-density lipoprotein biology.protein lipids (amino acids peptides and proteins) Rabbits Antibody business |
| Zdroj: | Diabetologia. 35(3) |
| ISSN: | 0012-186X |
| Popis: | Hyperglycaemia in diabetes mellitus is responsible for the process of non-enzymatic glycosylation of different proteins. Since we did not find elevated glycated apolipoprotein B levels in diabetic patients, an altered glycated apolipoprotein B metabolism was suspected in diabetic patients. Experiments in normal rabbits showed that non-reductive (in vitro) glycated low density lipoprotein (gly-LDL) was cleared at a slower rate than control LDL and thus stayed longer in the circulation (vascular mean residence time: 10 vs 8 h, p less than 0.001). The body mean residence time for gly-LDL was 22 h vs 17 h for control LDL. In diabetic animals the catabolic parameters of both LDL preparations changed towards a faster clearance, the effect being greatest for gly-LDL (total mean residence times of gly-LDL pre-diabetic: 19 h, diabetic: 16 h; control LDL pre-diabetic and diabetic: 14 h). The difference in clearance between glycated and control LDL was thus strongly reduced. Virtually no antibody complexed to gly-LDL could be measured. The results suggest an increased activity of the non-receptor mediated pathway in diabetes mellitus, possibly co-responsible for an increased atherosclerotic risk. |
| Databáze: | OpenAIRE |
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