Oxidative Stress in Cerebral Small Vessel Disease Dizziness Patients, Basally and After Polyphenol Compound Supplementation
| Autor: | Augusto Pietro Casani, Gabriele Siciliano, E Navari, E Ferrari, Lucia Chico, M C Caselli, N Cerchiai, L Ulivi, M Maccarrone, Nicola Giannini, Michelangelo Mancuso, V. Montano, Ubaldo Bonuccelli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Disease status Disease 030204 cardiovascular system & hematology medicine.disease_cause Biochemistry Gastroenterology Dizziness Article Pathogenesis 03 medical and health sciences 0302 clinical medicine Quality of life Internal medicine medicine Humans Molecular Biology Aged Aged 80 and over business.industry cerebral small vessel disease Leukoaraiosis Polyphenols General Medicine Middle Aged Cerebrovascular Disorders Oxidative Stress Cohort Dietary Supplements Molecular Medicine DHI Female Small vessel business 030217 neurology & neurosurgery Oxidative stress Biomarkers |
| Zdroj: | Current Molecular Medicine |
| ISSN: | 1875-5666 1566-5240 |
| Popis: | Background: Leukoaraiosis (LA) is a common radiological finding in elderly, frequently associated with several clinical disorders, including unexplained dizziness. The pathogenesis of LA is multifactorial, with a dysfunction of cerebral microcirculation resulting in chronic hypoperfusion and tissue loss, with oxidative stress involved in this cascade. Objective: The aim of this study was to analyse some oxidative stress biomarkers in a cohort of LA patients. Method: Fifty-five consecutive patients (33 males, median age 75 years) with LA were recruited. In a subgroup of 33 patients with LA and unexplained dizziness, we have then performed an open study to evaluate if 60-day supplementation with a polyphenol compound may modify these biomarkers and influence quality of life, analysed with the Dizziness Handicap Inventory (DHI) scale. Results: At baseline, blood oxidative stress parameters values were outside normal ranges and compared to matched healthy controls. After the two months supplementation, we observed a significant decrement of advanced oxidation protein products values and a significant improvement of DHI. Conclusion: Oxidative stress biomarkers may be useful to detect redox imbalance in LA and to provide non-invasive tools to monitor disease status and response to therapy. |
| Databáze: | OpenAIRE |
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