A 10-Year Prospective Study of Bone Mineral Density and Bone Turnover in Males and Females With Type 1 Diabetes
| Autor: | S. A. Paul Chubb, Timothy M. E. Davis, Jocelyn J. Drinkwater, Niklaus Kamber, Kun Zhu, Richard L. Prince, Wendy A. Davis, Emma J. Hamilton, Valentina Rakic |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism Clinical Biochemistry Physiology Biochemistry Body Mass Index Bone remodeling 0302 clinical medicine Endocrinology Bone Density Longitudinal Studies Prospective Studies 030212 general & internal medicine Prospective cohort study Bone mineral education.field_of_study Lumbar Vertebrae Femur Neck Age Factors Middle Aged Postmenopause Forearm medicine.anatomical_structure Female Bone Remodeling Adult musculoskeletal diseases medicine.medical_specialty Population 030209 endocrinology & metabolism Context (language use) 03 medical and health sciences Sex Factors Internal medicine medicine Humans Pelvic Bones education Femoral neck Type 1 diabetes business.industry Biochemistry (medical) medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 1 Multivariate Analysis business Body mass index Biomarkers |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 103:3531-3539 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2018-00850 |
| Popis: | Context In a previous community-based, cross-sectional study, males with type 1 diabetes (T1D) had lower bone mineral density (BMD) than did matched people without diabetes but females with T1D had normal BMD. Objective To determine whether BMD in the males continued to decline, the neutral effect of T1D on BMD in females persisted, and whether temporal BMD changes reflected changes in bone turnover markers. Design Longitudinal observational study. Setting Urban community. Patients Forty-eight of the original 102 original cross-sectional study participants (20 males, 28 females) of mean age 42.0 years and median diabetes duration 14.6 years at baseline who were restudied a mean of 10.3 years later. Main outcome measures BMD at total hip, femoral neck, lumbar spine (L1 to L4), and distal forearm. Biochemical bone turnover markers. Results After adjustment for age, body mass index (BMI), and renal function, there was no temporal change in BMD at the hip or forearm in the males (P ≥ 0.12), but lumbar spine BMD increased (P = 0.009). Females exhibited no statistically significant change in BMD in similar multivariable models that also included postmenopausal status, except a mild increase at the forearm (P = 0.046). Age- and sex-related changes in bone turnover markers paralleled those in general population studies. Conclusions There is a reduction in BMD in males with T1D that occurs early in the course of the disease but then stabilizes. BMD in females with T1D remains similar to that expected for age, BMI, and postmenopausal status. |
| Databáze: | OpenAIRE |
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