Is there an advantage in scoring early embryos on more than one day?
| Autor: | Jihoon Kim, John D. Biggers, Lucila Ohno-Machado, Catherine Racowsky |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors animal structures Treatment outcome Embryonic Development Fertilization in Vitro Biology Risk Assessment Embryo Culture Techniques Andrology Predictive Value of Tests Pregnancy medicine Humans Sperm Injections Intracytoplasmic Selection (genetic algorithm) Extramural Obstetrics Rehabilitation Obstetrics and Gynecology Embryo Original Articles Embryo morphology Embryo Transfer Embryo Mammalian Embryo transfer Treatment Outcome Reproductive Medicine Predictive value of tests embryonic structures Regression Analysis Female Ovum implantation Algorithms Maternal Age |
| Zdroj: | Human Reproduction. 24:2104-2113 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/humrep/dep198 |
| Popis: | This study was undertaken to determine what characteristics should be recorded on which days to build a predictive model for selection of Day 3 embryos.Embryos failing to form a clinical sac or that formed a viable fetus (toor =12 weeks), and transferred singly (n = 269) or in pairs (n = 1326) were scored for early cleavage and pronuclear status on Day 1, and cell number, fragmentation, and symmetry on Days 2 and 3, with number of nuclei per blastomere also recorded on Day 2. Seven candidate models were identified using a priori clinical knowledge and univariate analyses. Each model was fit on a training-set and evaluated on a test-set with resampling, with discrimination assessed using the area under the ROC curve (AUC) and calibration assessed using the Hosmer-Lemeshow statistics.Models built using Day 1, 2 or 3 scores independently on the 30 resampled data sets showed that Day 1 evaluations provided the poorest predictive value (median AUC = 0.683 versus 0.729 and 0.725, for Day 2 and 3). Combining information from Day 1, 2 and 3 marginally improved discrimination (median AUC = 0.737). Using the final Day 3 model fitted on the whole dataset, the median AUC was 0.732 (95% CI, 0.700-0.764), and 68.6% of embryos would be correctly classified with a cutoff probability equal to 0.3.Day 2 or Day 3 evaluations alone are sufficient for morphological selection of cleavage stage embryos. The derived regression coefficients can be used prospectively in an algorithm to rank embryos for selection. |
| Databáze: | OpenAIRE |
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