Overall survival in older patients with cancer
| Autor: | Ming Sun, Juhee Song, Meghan Sri Karuturi, Beatrice Jara-Almonte Edwards, Yunlong Geng, Peter Khalil, Richard E. Champlin, Vicente Valero, Colin P.N. Dinney, Linda Pang, Debasish Tripathy, Xiaotao Zhang |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Medicine (miscellaneous) 030204 cardiovascular system & hematology vitamin D deficiency 03 medical and health sciences 0302 clinical medicine Weight loss Internal medicine Neoplasms Medicine Humans 030212 general & internal medicine Karnofsky Performance Status Prospective cohort study Geriatric Assessment Depression (differential diagnoses) Aged Proportional Hazards Models Retrospective Studies Aged 80 and over Oncology (nursing) business.industry Cancer Retrospective cohort study General Medicine Middle Aged medicine.disease Comorbidity Survival Analysis Medical–Surgical Nursing Malnutrition Multivariate Analysis Female medicine.symptom business |
| Zdroj: | BMJ supportivepalliative care. 10(1) |
| ISSN: | 2045-4368 |
| Popis: | ObjectivesA growing number of patients with cancer are older adults. We sought to identify the predictors for overall survival (OS) in older adults with solid tumour and haematological malignancies between January 2013 and December 2016.MethodsRetrospective cohort study. A comprehensive geriatric assessment was performed, with a median follow-up of 12.8 months. Analysis: univariate and multivariate Cox proportional hazards regression analysis.ResultsIn this study, among the 455 patients with last follow-up date or date of death, 152 (33.4%) died during the follow-up. The median follow-up is 12.8 months (range 0.2–51.1 months) and the median OS is 20.5 months (range 0.3–44.5 months). Among all older patients with cancer, predictors of OS included male gender, cancer stage, malnutrition, history of smoking, heavy alcohol use, frailty, weight loss, major depression, low body weight and nursing home residence. Traditional performance scores (Eastern Cooperative Oncology Group (ECOG) and Karnofsky Performance Scale (KPS)) were predictors of OS. Independent predictors included age >85 years and haematological malignancies. Among solid tumours (n=311) in addition to the above predictors, comorbidity, gait speed and vitamin D deficiency were associated with OS.ConclusionsWe identified specific geriatric factors associated with OS in older patients with cancer, and comparable in predictive ability to traditional performance scores such as KPS and ECOG. Prospective studies will be necessary to confirm our findings. |
| Databáze: | OpenAIRE |
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