Regulation of Porcine Endogenous Retrovirus Release by Porcine and Human Tetherins
| Autor: | Giada Mattiuzzo, Sabrina Ivol, Yasuhiro Takeuchi |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Swine
Xenotransplantation medicine.medical_treatment Molecular Sequence Data Transplantation Heterologous Immunology Antiviral protein Endogenous retrovirus Endogeny Biology GPI-Linked Proteins Microbiology Cell Line Animals Genetically Modified Viral envelope Antigens CD Zoonoses Virology Vaccines and Antiviral Agents medicine Animals Humans Protein Isoforms Amino Acid Sequence Swine Diseases Membrane Glycoproteins Endogenous Retroviruses Transplantation Cell culture Insect Science Tetherin Sequence Alignment |
| Zdroj: | Journal of Virology. 84:2618-2622 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | The risk of transmission of porcine endogenous retrovirus (PERV) is one of the major safety issues in xenotransplantation. Human tetherin, recently described as an antiviral protein able to inhibit the release of enveloped viruses, and its porcine homologue were shown to inhibit PERV release from producer cells, establishing themselves as candidate molecules to suppress PERV production in porcine xenografts by animal engineering. |
| Databáze: | OpenAIRE |
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