Chronic stress effects and their reversibility on the Fallopian tubes and uterus in rats
Autor: | Hanumant Narasinhacharya Yajurvedi, S. Divyashree |
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Rok vydání: | 2017 |
Předmět: |
Restraint
Physical medicine.medical_specialty Antioxidant Time Factors medicine.medical_treatment Uterus 030209 endocrinology & metabolism Reproductive technology Biology Endometrium medicine.disease_cause Antioxidants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Malondialdehyde Genetics medicine Animals Insulin Chronic stress Testosterone Rats Wistar Molecular Biology Fallopian Tubes Swimming 030219 obstetrics & reproductive medicine Estradiol Recovery of Function Disease Models Animal Oxidative Stress medicine.anatomical_structure Reproductive Medicine chemistry Chronic Disease Animal Science and Zoology Female Oxidative stress Stress Psychological Developmental Biology Biotechnology |
Zdroj: | Reproduction, fertility, and development. 30(2) |
ISSN: | 1031-3613 |
Popis: | The durational effects of chronic stress on the Fallopian tubes and uterus were studied by exposing rats to stressors in the form of restraint (1 h) and forced swimming (15 min) daily for 4, 8 or 12 weeks. One group of stressed rats from each time period was then maintained without exposure to stressors for a further 4 weeks to assess their ability to recover from stress. All time periods of stress exposure resulted in decreased weight of the body and Fallopian tubes; however, the relative weight of the uterus and serum concentrations of oestradiol and insulin increased significantly. The antioxidant potential was decreased with increased malondialdehyde concentrations in the Fallopian tubes following all durations of exposure and after 4 and 8 weeks of stress exposure in the uterus. Interestingly, rats stressed for 12 weeks showed an increase in serum testosterone concentration and antioxidant enzyme activities with a decrease in malondialdehyde concentration in the uterus. The antioxidant enzyme activities and malondialdehyde concentration in the Fallopian tubes of all recovery group rats were similar to stressed rats. However, in the uterus these parameters were similar to controls in recovery group rats after 4 weeks or 8 weeks of exposure, but after 12 weeks of stress exposure these parameters did not return to control levels following the recovery period. These results reveal, for the first time, that chronic stress elicits an irreversible decrease in antioxidant defence in the Fallopian tubes irrespective of exposure duration, whereas the uterus develops reversible oxidative stress under short-term exposure but increased antioxidant potential with endometrial proliferation following long-term exposure. |
Databáze: | OpenAIRE |
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