Le testicule fœtal est-il en danger ?
| Autor: | Christine Levacher, René Habert, Geraldine Delbes, Clotilde Duquenne |
|---|---|
| Přispěvatelé: | Gametogenèse et génotoxicité (UMR_S_566 ), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-IFR13-Institut National de la Santé et de la Recherche Médicale (INSERM), Maylin, Françoise, IFR13-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2005 |
| Předmět: |
MESH: Xenobiotics
medicine.medical_specialty MESH: Estrogens Ovarian hormone General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Animal model medicine MESH: English Abstract [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Gynecology MESH: Humans 030219 obstetrics & reproductive medicine MESH: Testis business.industry MESH: Infant Newborn Germinal cell [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology General Medicine [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Infant newborn MESH: Male 3. Good health 030220 oncology & carcinogenesis business |
| Zdroj: | médecine/sciences médecine/sciences, EDP Sciences, 2005, 21 (12), pp.1083-8 médecine/sciences, 2005, 21 (12), pp.1083-8 |
| ISSN: | 1958-5381 0767-0974 |
| DOI: | 10.1051/medsci/200521121083 |
| Popis: | Estrogens are classically known to play a major role in female reproduction, but there is now compelling evidence that they may also be involved in the regulation of male reproductive function. In humans, a decrease in sperm count and an increase in the incidences of testicular cancer, cryptorchidism and hypospadia have been observed in many countries over the last 50 years. Male reproductive alterations were also observed in wildlife. Such male reproductive disorders have been attributed to the increase in concentration of xenobiotics, and of xenoestrogens in particular, in the environment and in food. Epidemiological, clinical and experimental studies have suggested that excessive exposure to estrogens during fetal/neonatal life can lead to reproductive disorders in adulthood. Using an in vitro model, we showed that estrogens directly affected the development of the fetal testis. Lastly, we clearly demonstrated that the fetal and neonatal testis is very sensitive to estrogens since the invalidation of estrogen receptor alpha leads to an increase of steroidogenesis and the invalidation of estrogen receptor beta enhances the development of the germ cell lineage in the male. |
| Databáze: | OpenAIRE |
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